jules levin, NATAP: testosterone & frailty in older men (0111)


wikipedia on the “five components of frailty” mentioned below: “Frailty is determined based on cutoffs in 5 components – Muscle weakness, weight loss, low physical activity, exhaustion, and slow walking speed.”



These observations suggest that there may be an association between frailty and low sex hormone levels in older men. The only cross-sectional report that 

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jules levin, NATAP: JCEM editorial on testosterone/estradiol & bone loss (0110)

NATAP: Testosterone/estradiol & Bone Loss

“Although previous studies in men had shown that serum estradiol levels were related to bone density (4) and that estrogen regulated bone turnover (5, 6) and bone loss (7) in elderly men, more recent studies have now also demonstrated that serum estradiol, and not serum testosterone, levels are the most robust hormonal predictors of fracture risk in aging men (8, 9, 10). What is perhaps somewhat surprising from the study of Burnett-Bowie et al. (2) is that relatively small reductions in estradiol levels appear to significantly modulate rates of bone loss. Although this may reflect just how heavily leveraged the male skeleton is on circulating estrogen levels, an alternate explanation for this finding is that changes in serum estradiol levels may not fully reflect reductions in local estrogen production in osteoblastic cells (11), and the extent of skeletal estrogen deficiency induced by anastrozole may therefore be underestimated by serum estradiol measurements.”

“The findings of Burnett-Bowie et al. (2) also need to be placed in the context of previous trials of testosterone replacement in older men. Thus, Amory et al. (12) found that 200 mg of im testosterone every 2 wk increased spine BMD by 10% and total hip BMD by 3%. By contrast, effects of transdermal testosterone on bone density have been marginal (13), suggesting that the higher testosterone levels associated with im treatment may be necessary for achieving beneficial skeletal effects. Based on the evidence provided by Burnett-Bowie et al. (2), it is probable that it is the higher estradiol levels associated with the higher testosterone levels (rather than the testosterone levels themselves) that are necessary for optimal skeletal benefits.”

Testosterone: More Is Not Always Better

The Journal of Clinical Endocrinology & Metabolism Vol. 94, No. 12 4665-4667

Sundeep Khosla

Endocrine Research Unit, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905

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pop & health infoshare: links to HIV/AIDS & aging in thailand & cambodia (0109)


haven’t had a chance to start mining this yet, but it promises to be a productive set of links from the population studies center in ann arbor


AIDS and Older Persons: Studies of the Impact in Thailand and Cambodia

Two teams of US researchers have worked in colaboration with Thai and Cambodian researchers to study the impact of AIDS on older persons in Thailand and Cambodia. Data collection for Thailand spans 1998-2009; data collection in Cambodia spans 2004-2007. Funding has been provided by the U.S. National Institute on Aging. The projects utilize a multi-method approach and aim to provide a comprehensive assessment of a wide range of impacts on older persons, especially parents of those who die, and their implications for understanding the impact on older persons in other settings.

Additional Information

HIV/AIDS is usually viewed as a disease affecting reproductive-age adults and their infant children. Discussions rarely consider the impact on older persons and, when they do, they typically focus on those who are infected themselves. Not only can older adults contract HIV themselves but a far greater number of older persons are affected through the infection of significant others, especially their adult children. The pathways through which they are affected include caregiving, coresidence and providing financial and material support during the illness, paying funeral expenses, fostering orphaned grandchildren, losing current and old-age support that the child would have provide, and suffering grief and emotional stress. These in turn can have profound consequences for their economic, social, psychological, and physical well-being. At the same time, by playing a major role in caregiving, older persons make significant contributions to the well-being of their infected sons and daughters and, by assuming the role of foster parents, to the grandchildren who are left behind.

[links to documents after jump]

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research network on HIV/AIDS & the elderly: links to studies 1999 – present (0108)

Research Network on HIV/AIDS and the Elderly

The list consists of published and unpublished studies by network members that examine impact of the HIV/AIDS epidemic on older persons. If your publications or reports in this area are not yet listed or if you have new ones please send the citation to us to add to the list.

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commemorating the first long night that ended when raven stole the sun & moon & stars & put them in the sky

kearns to LA city council: HIV/AIDS elder summit & new media training in bradley conference center set for valentine’s weekend (0106)

[december 15, 2009] good morning president
garcetti, distinguished council members. i
have given the clerk copies of my prepared

my name is richard kearns. i am a
58-year-old gay man living with AIDS
in los angeles for more than
20 years, an angelino poet advocate.

i am delighted to announce to you
this morning that
on friday, february 12th, 2010,
upstairs in the
tom bradley conference center,
on the 27th floor,
we will hold,

LA city
advocacy summit
& new media

“new tricks
for old dogs &
their allies”

sponsored by
councilmember bill rosendahl &
the city AIDS coordinators office

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kearns: save the date (feb 12, 2010) for LA city grassroots elder HIV/AIDS sdvocacy summit & new media training (0105)

text of jpeg after jump

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